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He is best known for arguing that the complexity of biological systems and organisms might result as much from self-organization and far-from-equilibrium dynamics as from Darwinian natural selection, as discussed in his book Origins of Order (1993). In 1967 and 1969 he used random Boolean networks to investigate generic self-organizing properties of gene regulatory networks, proposing that cell types are dynamical attractors in gene regulatory networks and that cell differentiation can be understood as transitions between attractors. Recent evidence suggests that cell types in humans and other organisms are attractors. In 1971 he suggested that a zygote may not be able to access all the cell type attractors in its gene regulatory network during development and that some of the developmentally inaccessible cell types might be cancer cell types. This suggested the possibility of "cancer differentiation therapy". He also proposed the self-organized emergence of collectively autocatalytic sets of polymers, specifically peptides, for the origin of molecular reproduction, which have found experimental support.
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SSRN Electronic Journal (2023)
SSRN Electronic Journal (2023)
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STRATEGIC MANAGEMENT JOURNALno. 6 (2023): 1514-1533
Gonen Ashkenasy,Stuart Kauffman,Doron Lancet,Sijbren Otto, Kepa Ruiz-Mirazo, Sergey Semenov,Joana Xavier
Cell Reports Physical Scienceno. 10 (2023): 101594-101594
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arxiv(2022)
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