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个人简介
Modifications to DNA, as part of normal cellular processes or as aberrations, can have profound biological consequences. The major thrust of my research program is to study these nucleic acid modifications in the context of enzymes and proteins that either generate or recognize them.
DNA polymerases, which faithfully replicate DNA, stumble when they encounter oxidized DNA lesions. These enzymes will either stall at the site of lesion or bypass it, initiating translesion synthesis. Uncovering the fundamental mechanisms underpinning lesion bypass is paramount to understand the initial events of mutagenesis. Our work focuses of human DNA polymerases, including polymerases beta and theta, which function in base excision repair and double strand break repair, respectively. Funded by NCI R01 CA52040 and CA080830.
Several DNA repair processes are in place to minimize damage in DNA. One of these processes is called base excision repair (BER). The first step in BER is carried out by DNA glycosylases, enzymes that locate and excise damaged base lesions. Our goal is to delineate the structural features of human DNA glycosylases that are involved in the recognition of DNA base damage induced by ionizing radiation. Our focus is on glycosylases that repair oxidized bases: the Nei-like enzymes (NEIL1-3), and NTHL1 glycosylase. This work is part of a program project grant funded by NCI (P01 CA098993). Additional funding from the Trunk Foundation is gratefully acknowledged.
研究兴趣
论文共 225 篇作者统计合作学者相似作者
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Journal of Biological Chemistrypp.107461, (2024)
Journal of Biological Chemistryno. 1 (2024): 105503-105503
MOLECULAR CELLno. 8 (2024): 1626-1626
Carel Fijen, Lea Drogalis Beckham, Dante Terino, Yuzhen Li,Dale A. Ramsden,Richard D. Wood,Sylvie Doublie,Eli Rothenberg
crossref(2023)
Nucleic acids researchno. 22 (2023): 12508-12521
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2023): 88-88
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NATUREno. 7988 (2023): 836-+
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#Papers: 225
#Citation: 7235
H-Index: 41
G-Index: 84
Sociability: 6
Diversity: 0
Activity: 1
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