基本信息
浏览量:18
职业迁徙
个人简介
Research Description
The heart is a highly metabolic organ and as such is full of energy-producing mitochondria. During a heart attack, blockage of a coronary artery prevents blood flow to part of the heart, a condition termed ischaemia. As a result, the mitochondria in this tissue are deprived of oxygen and energy production stops. We have demonstrated that one of the mitochondrial fuels, succinate, is build up during ischaemia and decreases again rapidly as soon as the blood flow is restored. During this so-called reperfusion phase succinate is actually consumed by the mitochondria via an alternative route that does not produce energy but instead produces oxygen radicals that destroy the heart muscle. Because lost heart muscle cannot be regenerated the patient is left with a weakened heart and heart failure often occurs. Our research is directed toward identifying therapies that prevent cell death in ischaemic heart and the subsequent development of heart failure. In addition, we aim to develop treatment strategies targeting heart failure in disease models such as obesity, type 1 and type 2 diabetes, and ageing.
The heart is a highly metabolic organ and as such is full of energy-producing mitochondria. During a heart attack, blockage of a coronary artery prevents blood flow to part of the heart, a condition termed ischaemia. As a result, the mitochondria in this tissue are deprived of oxygen and energy production stops. We have demonstrated that one of the mitochondrial fuels, succinate, is build up during ischaemia and decreases again rapidly as soon as the blood flow is restored. During this so-called reperfusion phase succinate is actually consumed by the mitochondria via an alternative route that does not produce energy but instead produces oxygen radicals that destroy the heart muscle. Because lost heart muscle cannot be regenerated the patient is left with a weakened heart and heart failure often occurs. Our research is directed toward identifying therapies that prevent cell death in ischaemic heart and the subsequent development of heart failure. In addition, we aim to develop treatment strategies targeting heart failure in disease models such as obesity, type 1 and type 2 diabetes, and ageing.
研究兴趣
论文共 158 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Redox biologypp.103210-103210, (2024)
Basic Research in Cardiologypp.1-7, (2024)
International journal of molecular sciencesno. 11 (2024): 6242-6242
Jan Lj Miljkovic,Nils Burger,Justyna M. Gawel,John F. Mulvey,Abigail A. Norman,Jordan Morris,Takanori Nishimura,Yoshiyuki Tsujihata,Angela Logan,Olga Sauchanka,Stuart T. Caldwell,Tracy A. Prime,Georgina Bates,Dunja Aksentijevic,Hiran Prag,Julien Prudent,Andrew M. James,Thomas Krieg,Richard Hartley, Michael Murphy
Free radical biology & medicine (2023): S132-S133
Redox biology (2023): 102600-102600
Aleksandra Boikova,Gregory A. Quaife-Ryan,Christopher Batho,Elsa Lawrence,Harley Robinson,Camilla Ascanelli,Karin Jennbacken,Qingdong Wang,Kenny M. Hansson, Angela Seaton, Victoria Rodriguez Noci,Megan J. Bywater,Jasmin Straube,Kamil A. Sokolowski,Brian Wc Tse,Thomas Krieg,Ana Vujić,Enzo R. Porrello,Sanjay Sinha,James E. Hudson,Catherine H. Wilson
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Mariann Gyöngyösi,Pilar Alcaide,Folkert W Asselbergs, J,Giovanni G Camici,Paula da Costa Martins,Péter Ferdinandy,Marianna Fontana,Henrique Girao,Massimiliano Gnecchi,Can Gollmann-Tepeköylü,Petra Kleinbongard,Thomas Krieg,Rosalinda Madonna,Melanie Paillard,Antonis Pantazis,Cinzia Perrino,Maurizio Pesce,Gabriele G Schiattarella,Joost P G Sluijter,Sabine Steffens,Carsten Tschöpe,Sophie Van Linthout,Sean M Davidson
Gerd Heusch,Ioanna Andreadou,Robert Bell,Edoardo Bertero,Hans-Erik Botker,Sean M. Davidson,James Downey,Philip Eaton,Peter Ferdinandy,Bernard J. Gersh,Mauro Giacca,Derek J. Hausenloy, Borja Ibanez,Thomas Krieg,Christoph Maack,Rainer Schulz,Frank Sellke,Ajay M. Shah,Holger Thiele,Derek M. Yellon,Fabio Di Lisa
Redox biology (2023): 102894-102894
European Heart Journalno. Supplement_2 (2023)
加载更多
作者统计
#Papers: 157
#Citation: 9132
H-Index: 44
G-Index: 95
Sociability: 7
Diversity: 3
Activity: 51
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn