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My research focusses on the development of novel non-invasive MRI methods which visualise blood flowing through the arteries that feed the brain and the resulting perfusion of the brain tissue. In particular, I am interested in techniques which allow blood from individual feeding arteries to be followed through the vascular tree. In addition to providing information about the structural and functional status of each artery, these methods allows the assessment of "collateral blood flow". This is when the main feeding artery to a certain brain region becomes blocked or significantly narrowed, but the flow of blood from secondary arteries maintains perfusion in this brain region, preventing a significant stroke. The presence or absence of collateral flow can be important in deciding between potential treatment options in patients with arterial disease. These vessel-selective strategies also have applications in diseases where the arterial source of blood flow is important, such as tumours and arteriovenous malformations.
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Magnetic resonance in medicineno. 2 (2023): 432-443
Winok Lapidaire,Nils D Forkert,Wilby Williamson,Odaro Huckstep, Cheryl Mj Tan,Maryam Alsharqi,Afifah Mohamed,Jamie Kitt, Holger Burchert,Pauline Mouches,Helen Dawes,Charlie Foster,
Russell A. Poldrack,Christopher J. Markiewicz,Stefan Appelhoff, Yoni K. Ashar,Tibor Auer,Sylvain Baillet, Shashank Bansal,Leandro Beltrachini,Christian G. Benar,Giacomo Bertazzoli, Suyash Bhogawar,Ross W. Blair,
ArXiv (2023)
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