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Our lab is interested in the underlying molecular mechanisms of gene expression in human mitochondria and bacteria. We use a combination of biochemical and structural biology approaches to study how RNA polymerase, the central enzyme in gene expression, contributes to gene regulation via transcriptional pausing; how it couples RNA synthesis to DNA replication, RNA processing and translation in mitochondria; and how we can control these processes to rationally manipulate gene expression for antimicrobials and treatments of disease. Students in the lab are trained in enzymology (e.g., kinetics, in vitro assays) and state-of-the-art structural methods (e.g., single-particle cryo-EM).
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论文共 33 篇作者统计合作学者相似作者
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bioRxiv : the preprint server for biology (2023)
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bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Christine Stephen,Tatiana V Mishanina
The Journal of biological chemistryno. 9 (2022): 102302
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