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Kaufman's current research still heavily involves the HOX gene. He is currently interested in proteome changes in the head of the aging Drosophila. In his personal statement for the National Academy of Sciences he states that "The goal of my laboratory is to contribute to an understanding of the genetic regulation development of higher organisms. The homeotic (Hox) genes of Drosophila melanogaster have been our principal focus. Homeotic lesions cause one portion of the animal to be transformed into an identity normally found elsewhere. The role of the Hox genes is best viewed as a set of developmental switches for decisions of segmental fate. The encoded homeodomain has shown that this switch activity is carried out through the transcriptional regulation of target genes." He has expanded his research from Drosophila to include several other insects and members of other subphylums under the phylum Arthopoda, such as Crustacea, Chelicerata and Myriapoda. He uses the technique of RNA-mediated gene inhibition (RNAi) to study the evolution of the HOX gene.
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Journal of Visualized Experiments (2023)
L Sian Gramates, Julie Agapite,Helen Attrill,Brian R Calvi,Madeline A Crosby, Gilberto Dos Santos,Joshua L Goodman,Damien Goutte-Gattat,Victoria K Jenkins,Thomas Kaufman,Aoife Larkin, Beverley B Matthews,
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