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Dr. Jeitner is interested in proteinaceous aggregation in neurodegenerative disorders. For example, during bleeding, proteins aggregate, forming clots that stem blood loss. Transglutaminases, which facilitate this aggregation, catalyze the formation of chemical bonds between aggregating proteins. The aberrant activation of these enzymes can contribute to pathological states, such as Alzheimer’s and Parkinson’s disease. According to the Braak Hypothesis—a major hypothesis for how Alzheimer’s and Parkinson’s diseases start—aggregated proteins, traveling from the periphery to the brain, cause neuronal losses.
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论文共 58 篇作者统计合作学者相似作者
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Nuclear Medicine and Biology (2023): 108508
GEROSCIENCE (2023)
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Chul-Hee Lee,Onorina Laura Manzo,Luisa Rubinelli, Sebastian E. Carrasco, Sungyun Cho,Thomas M. Jeitner,John W. Babich,Annarita Di Lorenzo,James M. Kelly
bioRxiv (Cold Spring Harbor Laboratory) (2023)
The Journal of pharmacology and experimental therapeuticsno. 3 (2022): 204-216
The Journal of Nuclear Medicine (2021): 1514-1514
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