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Research Summary
Exploring how a cell consumes itself -- Macroautophagy is classically defined as a pathway for the nonspecific sequestration and degradation of cytosolic material when the cell is faced with persistent starvation. This cytosolic material is captured within a double-membraned vesicle (the autophagosome) which forms de novo and ultimately traffics the material to the lysosome for degradation (and release of valuable nutrients). However, this pathway can also be utilized as a stress response to a wide variety of specific cellular insults. The ability to capture and degrade specific cytoplasmic targets including protein aggregates, invading pathogens or even whole dysfunctional organelles forms the basis of the cell’s response to diseases ranging from neurodegeneration to cancer and heart disease. In each case, large cytoplasmic targets are identified and encapsulated newly-formed autophagosomes for delivery to the lysosome. How these targets are identified and how this organelle forms are the major foci of our laboratory.
Specialized Terms: Macroautophagy; Autophagy
Exploring how a cell consumes itself -- Macroautophagy is classically defined as a pathway for the nonspecific sequestration and degradation of cytosolic material when the cell is faced with persistent starvation. This cytosolic material is captured within a double-membraned vesicle (the autophagosome) which forms de novo and ultimately traffics the material to the lysosome for degradation (and release of valuable nutrients). However, this pathway can also be utilized as a stress response to a wide variety of specific cellular insults. The ability to capture and degrade specific cytoplasmic targets including protein aggregates, invading pathogens or even whole dysfunctional organelles forms the basis of the cell’s response to diseases ranging from neurodegeneration to cancer and heart disease. In each case, large cytoplasmic targets are identified and encapsulated newly-formed autophagosomes for delivery to the lysosome. How these targets are identified and how this organelle forms are the major foci of our laboratory.
Specialized Terms: Macroautophagy; Autophagy
研究兴趣
论文共 78 篇作者统计合作学者相似作者
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Philip J. Mannino, Andrew Perun, Ivan Surovstev,Nicholas R. Ader,Lin Shao,Thomas J. Melia,Megan C. King,C. Patrick Lusk
bioRxiv (Cold Spring Harbor Laboratory) (2024)
Justin L Korfhage,Neng Wan, Helin Elhan, Lisa Kauffman, Mia Pineda,Devin M Fuller,Abdou Rachid Thiam,Karin M Reinisch,Thomas J Melia
bioRxiv : the preprint server for biology (2023)
biorxiv(2022)
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作者统计
#Papers: 79
#Citation: 7021
H-Index: 34
G-Index: 55
Sociability: 6
Diversity: 3
Activity: 42
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