基本信息
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Bio
I am a clinically trained scientist with over 40 years of experience, publisher of sixty-six scientific papers, describing novel concepts in theoretical and clinical research in leading medical journals, such as JAMA, Lancet Infectious Diseases, Nature, Hepatology, Vaccine, Journal of Clinical Oncology, Cellular Immunology, Transfusion, International Journal of Cancer, and others. Some of my papers were groundbreaking.
The publication of the first successful Newcastle Disease Virus (NDV) treatment of a patient with recurrent high-grade glioblastoma resistant to all conventional therapies preceded the explosion of papers on oncolytic viruses by many years. By now, 20 clinical trials have been conducted or initiated using attenuated strains of 7 different oncolytic viruses against glioblastoma multiforme.
The proof-of-principle superinfection treatment trials of viral hepatitis patients argued for the feasibility of exploiting viral competition between a non pathogenic and a pathogenic virus. Superinfection could become a groundbreaking technology for the treatment of other persistent viral infections such as caused by the human immunodeficiency virus (HIV).
In addition to the clinical studies I proposed a paradigm shift in the mammalian immune theory. The new theory explains the immune-related adverse events (irAEs) of the anti-CTLA-4 monoclonal antibody, Ipilimumab (Yervoy), occurring in 64.2% of the melanoma patients and the correlation between grade 3 and 4 irAEs and its clinical efficacy.
Using physicochemical charge-based methods I was the first to achieve ~ 5% CD34+ cell yields from single umbilical cord blood donations, ~10 times higher than the generally reported yields holding great promise for CD34+ cell therapy of adults.
Research Interests
Papers共 128 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
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引用量
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期刊级别
合作者
合作机构
JCO PRECISION ONCOLOGY (2024)
Pharmaceuticalsno. 2 (2023): 226-226
Frontiers in Immunology (2022)
crossref(2021)
Cureus (2021)
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Author Statistics
#Papers: 128
#Citation: 1969
H-Index: 24
G-Index: 36
Sociability: 5
Diversity: 3
Activity: 4
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