基本信息
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职业迁徙
个人简介
he primary focus of research in the group is the regulation of the Wnt signal transduction pathway.
Wnts together with other peptide ligands including the FGF, EGF, TGF-β and hedgehog families orchestrate
cell-cell interactions throughout development. Much of the specificity of each ligand's function is controlled
by intracellular pathways that are activated at the cell surface. Components of the Wnt/β-catenin pathway are
frequently mutated in human cancer. This laboratory studies normal and oncogenic Wnt signalling using
approaches ranging from biochemistry/structural biology, through cell and organoid based assays
to murine models.
Specific projects include:
1.The biochemistry of Wnt pathway components such as the kinase GSK-3
2.The identification of novel Wnt regulators through high throughput cDNA, siRNA and drug screening.
3.The analysis of normal and oncogenic Wnt signalling using murine models and 3D organoid culture systems.
4.The loss of the Axin anti-oncogenes in liver cancer.
Wnts together with other peptide ligands including the FGF, EGF, TGF-β and hedgehog families orchestrate
cell-cell interactions throughout development. Much of the specificity of each ligand's function is controlled
by intracellular pathways that are activated at the cell surface. Components of the Wnt/β-catenin pathway are
frequently mutated in human cancer. This laboratory studies normal and oncogenic Wnt signalling using
approaches ranging from biochemistry/structural biology, through cell and organoid based assays
to murine models.
Specific projects include:
1.The biochemistry of Wnt pathway components such as the kinase GSK-3
2.The identification of novel Wnt regulators through high throughput cDNA, siRNA and drug screening.
3.The analysis of normal and oncogenic Wnt signalling using murine models and 3D organoid culture systems.
4.The loss of the Axin anti-oncogenes in liver cancer.
研究兴趣
论文共 102 篇作者统计合作学者相似作者
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Kenneth Ewan, Bożena Pająk,Mark Stubbs, Helen Todd,Olivier Barbeau,Camilo Quevedo,Hannah Botfield,Rodrigo Young,Ruth Ruddle,Lee Samuel,Alysia Battersby,Florence Raynaud,
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Kenneth Ewan, Bożena Pająk,Mark Stubbs, Helen Todd,Olivier Barbeau,Camilo Quevedo,Hannah Botfield,Rodrigo Young,Ruth Ruddle,Lee Samuel, Alysia Battersby,Florence Raynaud,
crossref(2023)
Kenneth Ewan, Bożena Pająk,Mark Stubbs, Helen Todd,Olivier Barbeau,Camilo Quevedo,Hannah Botfield,Rodrigo Young,Ruth Ruddle,Lee Samuel, Alysia Battersby,Florence Raynaud,
crossref(2023)
crossref(2023)
Kenneth Ewan, Bożena Pająk,Mark Stubbs, Helen Todd,Olivier Barbeau,Camilo Quevedo,Hannah Botfield,Rodrigo Young,Ruth Ruddle,Lee Samuel, Alysia Battersby,Florence Raynaud,
crossref(2023)
Kenneth Ewan, Bożena Pająk,Mark Stubbs, Helen Todd,Olivier Barbeau,Camilo Quevedo,Hannah Botfield,Rodrigo Young,Ruth Ruddle,Lee Samuel, Alysia Battersby,Florence Raynaud,
crossref(2023)
crossref(2023)
Kenneth Ewan, Bożena Pająk,Mark Stubbs, Helen Todd,Olivier Barbeau,Camilo Quevedo,Hannah Botfield,Rodrigo Young,Ruth Ruddle,Lee Samuel, Alysia Battersby,Florence Raynaud,
crossref(2023)
Kenneth Ewan, Bożena Pająk,Mark Stubbs, Helen Todd,Olivier Barbeau,Camilo Quevedo,Hannah Botfield,Rodrigo Young,Ruth Ruddle,Lee Samuel, Alysia Battersby,Florence Raynaud,
crossref(2023)
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