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My research focuses on the role of steroid hormones in amphibian development and I conduct both laboratory and field studies in the U.S. and Africa. The two main areas of interest are metamorphosis and sex differentiation, but I am also interested in growth (larval and adult) and hormonal regulation of aggressive behavior. My work addresses problems on several levels including ecological, organismal, and molecular questions. In my work on metamorphosis, I study a local toad (Bufo boreas). Studies examine the effects of temperature on developmental rates, interactions between the thyroid hormones and steroids, and hormonal regulation of skin gland development. I am also examining the effects of tadpole density on developmental rates and measuring metamorphic rates and hormone levels of tadpoles in the field and in the laboratory. My work on sex differentiation involves the African clawed frog (Xenopus laevis), the Japanese kajika (Buegeria buegeri), and the Pine Barrens treefrog (Hyla femoralis). While Xenopus serves as a good model because of its availability, the latter two species have genetically distinguishable sexes. I can therefore examine early events in gonad differentiation, steroid enzyme activities, steroid receptors, etc., knowing the genetic sex of the individual larvae.
研究兴趣
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Journal of Pharmacology and Experimental Therapeuticspp.JPET-001832, (2023)
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Estephannie Alvarez, Sydney Yoon, Jhoselyn Pineda, Ashlie Barillas, Christopher Harrod, Yoonjeong Choi, Alexia Anous, Malik Alhadi,Tyrone Hayes
INTEGRATIVE AND COMPARATIVE BIOLOGY (2023): S10-S10
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INTEGRATIVE AND COMPARATIVE BIOLOGY (2023): S136-S137
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SCIENCEno. 6510 (2020): 1440-1441
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ELEMENTA-SCIENCE OF THE ANTHROPOCENE (2017)
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