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Research activities in my group are focused in the area of molecular biology of eubacteria. We use Escherichia coli and mycobacteria as model organisms, and exploit various heterologous systems to address mechanistic issues relevant to protein synthesis, and DNA repair pathways. Advances in our understanding of the process of protein synthesis are fundamental to development of novel strategies in broader areas of biotechnology, medicine and agriculture. As to our studies in the area of DNA repair, it is known that pathogenic mycobacteria are exposed to reactive oxygen species and reactive nitrogen intermediates within host macrophages. Both of these innate immune responses lead to DNA damage. Thus, we believe that our studies would contribute to the overall scientific endeavor of developing newer drug targets and the attenuated strains to control mycobacterial infections such as tuberculosis, which has attained the status of global human health problem.
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MOLECULAR MICROBIOLOGY (2024)
Journal of Biosciencesno. 4 (2023): 1-4
Nucleic acids researchno. 13 (2023): 6554-6565
European journal of medicinal chemistry (2023): 115604-115604
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