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The Macromolecular Structure and Interaction Laboratory combines macromolecular crystallography with biochemical and biophysical approaches to elucidate the molecular basis of biological processes at atomic detail.
One major area of research is concerned with the regulation of gene expression at the transcriptional as well as translational level. We study promoter and enhancer recognition by transcription factors to understand their function in transcription initiation as well as RNA-binding proteins that ensure mRNA homeostasis by regulating mRNA maturation, transport, translation and degradation.
In a second major area of research, we address problems of intracellular protein transport and sorting. Recently, we have determined crystal structures of the abundant human AAA ATPase p97 bound to the adapter protein ASPL and revealed a novel mode of AAA ATPase regulation by UBX-domain proteins. Structure analyses of the transport protein particle (TRAPP) contributed to understanding the function of this complex in tethering transport vesicles at the cis-Golgi membrane.
One major area of research is concerned with the regulation of gene expression at the transcriptional as well as translational level. We study promoter and enhancer recognition by transcription factors to understand their function in transcription initiation as well as RNA-binding proteins that ensure mRNA homeostasis by regulating mRNA maturation, transport, translation and degradation.
In a second major area of research, we address problems of intracellular protein transport and sorting. Recently, we have determined crystal structures of the abundant human AAA ATPase p97 bound to the adapter protein ASPL and revealed a novel mode of AAA ATPase regulation by UBX-domain proteins. Structure analyses of the transport protein particle (TRAPP) contributed to understanding the function of this complex in tethering transport vesicles at the cis-Golgi membrane.
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NUCLEIC ACIDS RESEARCHno. 1 (2024): 370-384
Edgar Specker, Radoslaw Wesolowski,Anja Schuetz,Susann Matthes,Keven Mallow, Malgorzata Wasinska-Kalwa, Lars Winkler,Andreas Oder,Natalia Alenina,Dirk Pleimes,Jens Peter von Kries,Udo Heinemann,
Journal of medicinal chemistryno. 21 (2023): 14866-14896
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Yvette Roske, Florian Lindemann,Anne Diehl,Nils Cremer,Victoria A Higman, Brigitte Schlegel,Martina Leidert,Kristina Driller,Kürşad Turgay,Peter Schmieder,Udo Heinemann,Hartmut Oschkinat
BMC genomicsno. 1 (2023): 736-736
Edgar Specker,Susann Matthes,Radoslaw Wesolowski,Anja Schütz,Maik Grohmann,Natalia Alenina,Dirk Pleimes,Keven Mallow,Martin Neuenschwander, Angelina Gogolin,Marie Weise, Jochen Pfeifer,
CANCERSno. 2 (2021): 190
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