基本信息
浏览量:7
职业迁徙
个人简介
Research Interests
Dr. Dawson’s laboratory is actively engaged in discovering and defining cell signaling pathways that lead to either neuronal survival or neuronal death. The lab has named a new cell death process Parthanatos. In the brain, Parthanatos is important in ischemic and excitotoxic injury and in models of Parkinson’s disease. The cell death mechanism involves nuclear activation of poly(ADP-ribose) polymerase and mitochondrial release of apoptosis inducing factor in the integration of the death signal; current research aims to further understand how this pathway works. She has characterized neuronal injury and survival pathways in cell, fly and mouse models of Parkinson’s disease and stroke. She is focused on several monogenic forms of Parkinson’s disease including parkin and LRRK2, as well as the new sporadic model of Parkinson’s disease using pre-formed fibrils of alpha synulcein in order to begin to define the biochemical signaling important to Parkinson’s disease. Yeast, cellular, fly and mouse models along with human neuronal cultures and human postmortem tissue explore survival and disease signaling events relevant to Parkinson’s disease. . In addition to cell death, the team also strives to understand how cells survive by characterizing survival genes and proteins involved in preconditioning. The Dawson laboratory employs advanced technologies in high throughput screening, next generation sequencing including RNA Seq and ChIP Seq, ribosomal foot printing, and high throughput proteomic analysis coupled with advanced computational biology to investigate signaling networks important in stroke, Parkinson’s disease and other neurodegenerative disorders. The overarching goal of the research is to understand death and survival signaling in order to identify new targets for therapeutic development.
Dr. Dawson’s laboratory is actively engaged in discovering and defining cell signaling pathways that lead to either neuronal survival or neuronal death. The lab has named a new cell death process Parthanatos. In the brain, Parthanatos is important in ischemic and excitotoxic injury and in models of Parkinson’s disease. The cell death mechanism involves nuclear activation of poly(ADP-ribose) polymerase and mitochondrial release of apoptosis inducing factor in the integration of the death signal; current research aims to further understand how this pathway works. She has characterized neuronal injury and survival pathways in cell, fly and mouse models of Parkinson’s disease and stroke. She is focused on several monogenic forms of Parkinson’s disease including parkin and LRRK2, as well as the new sporadic model of Parkinson’s disease using pre-formed fibrils of alpha synulcein in order to begin to define the biochemical signaling important to Parkinson’s disease. Yeast, cellular, fly and mouse models along with human neuronal cultures and human postmortem tissue explore survival and disease signaling events relevant to Parkinson’s disease. . In addition to cell death, the team also strives to understand how cells survive by characterizing survival genes and proteins involved in preconditioning. The Dawson laboratory employs advanced technologies in high throughput screening, next generation sequencing including RNA Seq and ChIP Seq, ribosomal foot printing, and high throughput proteomic analysis coupled with advanced computational biology to investigate signaling networks important in stroke, Parkinson’s disease and other neurodegenerative disorders. The overarching goal of the research is to understand death and survival signaling in order to identify new targets for therapeutic development.
研究兴趣
论文共 330 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
crossref(2024)
bioRxiv : the preprint server for biology (2023)
引用0浏览0WOS引用
0
0
EMBO reportsno. 11 (2023): e56166-e56166
引用1浏览0WOS引用
1
0
Ageing and neurodegenerative diseasesno. 1 (2023): 5-5
Marjan Gharagozloo,Danny Galleguillos,Larissa Jank,Elias S. Sotirchos,Matthew D. Smith,Thomas Garton, Swati Kumar, Omar Hussein, Saahith Potluri,Michelle Taylor,Catherine Siu,Jackson W. Mace,
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeuticsno. 4 (2023): 1-12
Margaux Serey-Gaut,Marisol Cortes,Periklis Makrythanasis,Mohnish Suri,Alexander M R Taylor,Jennifer A Sullivan, Ayat N Asleh,Jaba Mitra,Mohamad A Dar, Amy McNamara,Vandana Shashi, Sarah Dugan,
Mira Menon Sachdeva,Ruth Marx-Rattner, Madhu S. Saddala,Shinwon Ha, Kaitlyn Clark,Dongsan Kim,Sung-Ung Kang,Jiang Qian,Valina L. Dawson,Ted M. Dawson
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCEno. 8 (2023)
引用0浏览0引用
0
0
Stefanie Krug, Manish Gupta,Pankaj Kumar, Laine Feller,Elizabeth A. Ihms,Bong Gu Kang,Geetha Srikrishna,Ted M. Dawson,Valina L. Dawson,William R. Bishai
Nature Communicationsno. 1 (2023): 1-15
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn