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Cell-cell adhesion is a fundamental biological process in tissue formation, embryogenesis and cancer development. Our research aims at understanding the physical and biomolecular mechanisms that underlies the formation of cell-cell junction in various conditions. One approach that we have taken is to use model cell systems to understand the dynamics and spatial organization of cadherin during the formation of the junction. We also develop physical approaches to test and measure the influence of mechanical tensions on the structure and dynamics of junction formation. Another approach is to study specific junction such as bile canaliculi formed between primary hepatocytes . Using microfabricated patterns with 3D protein coating we control the dynamics and position of bile canaliculi formation. Performing specifically developed techniques we image in real time the formation of the secretion tube and study how its formation is affected by physical parameters. Building on our experience with 3D protein coating in nano and microtextured environment, we are developing a platform for controlled cell culture, high resolution imaging and high through-put screening capabilities.
Cell-cell adhesion is a fundamental biological process in tissue formation, embryogenesis and cancer development. Our research aims at understanding the physical and biomolecular mechanisms that underlies the formation of cell-cell junction in various conditions. One approach that we have taken is to use model cell systems to understand the dynamics and spatial organization of cadherin during the formation of the junction. We also develop physical approaches to test and measure the influence of mechanical tensions on the structure and dynamics of junction formation. Another approach is to study specific junction such as bile canaliculi formed between primary hepatocytes . Using microfabricated patterns with 3D protein coating we control the dynamics and position of bile canaliculi formation. Performing specifically developed techniques we image in real time the formation of the secretion tube and study how its formation is affected by physical parameters. Building on our experience with 3D protein coating in nano and microtextured environment, we are developing a platform for controlled cell culture, high resolution imaging and high through-put screening capabilities.
Research Interests
Papers共 101 篇Author StatisticsCo-AuthorSimilar Experts
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NATURE METHODS (2024)
Chaoyu Fu,Florian Dilasser, Shao-Zhen Lin,Marc Karnat,Aditya Arora,Harini Rajendiran,Hui Ting Ong, Nai Mui Hoon Brenda, Sound Wai Phow,Tsuyoshi Hirashima,Michael Sheetz,Jean-François Rupprecht,Sham Tlili,Virgile Viasnoff
Proceedings of the National Academy of Sciencesno. 37 (2024)
Valentin Dunsing-Eichenauer,Johan Hummert,Claire Chardès,Thomas Schönau,Léo Guignard,Rémi Galland,Gianluca Grenci,Max Tillmann,Felix Koberling, Corinna Nock,Jean-Baptiste Sibarita,Virgile Viasnoff,Ivan Michel Antolovic,Rainer Erdmann,Pierre-François Lenne
crossref(2024)
Valentin Dunsing-Eichenauer,Sham Tlili,Claire Chardes,Remi Galland,Jean-Baptiste Sibarita,Virgile Viasnoff,Leo Guignard,Pierre-Francois Lenne
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERSno. SUPPL 1 (2023): S78-S78
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Aditya Arora,Mohd Suhail Rizvi,Gianluca Grenci,Florian Dilasser,Chaoyu Fu, Modhura Ganguly, Sree Vaishnavi, Kathirvel Paramsivam,Srikanth Budnar,Ivar Noordstra,Alpha S. Yap,Virgile Viasnoff
biorxiv(2023)
arXiv (Cornell University) (2023)
BIOIMAGINGpp.41-51, (2023)
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Author Statistics
#Papers: 101
#Citation: 4072
H-Index: 31
G-Index: 63
Sociability: 6
Diversity: 3
Activity: 39
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