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Cell-cell adhesion is a fundamental biological process in tissue formation, embryogenesis and cancer development. Our research aims at understanding the physical and biomolecular mechanisms that underlies the formation of cell-cell junction in various conditions. One approach that we have taken is to use model cell systems to understand the dynamics and spatial organization of cadherin during the formation of the junction. We also develop physical approaches to test and measure the influence of mechanical tensions on the structure and dynamics of junction formation. Another approach is to study specific junction such as bile canaliculi formed between primary hepatocytes . Using microfabricated patterns with 3D protein coating we control the dynamics and position of bile canaliculi formation. Performing specifically developed techniques we image in real time the formation of the secretion tube and study how its formation is affected by physical parameters. Building on our experience with 3D protein coating in nano and microtextured environment, we are developing a platform for controlled cell culture, high resolution imaging and high through-put screening capabilities.
Cell-cell adhesion is a fundamental biological process in tissue formation, embryogenesis and cancer development. Our research aims at understanding the physical and biomolecular mechanisms that underlies the formation of cell-cell junction in various conditions. One approach that we have taken is to use model cell systems to understand the dynamics and spatial organization of cadherin during the formation of the junction. We also develop physical approaches to test and measure the influence of mechanical tensions on the structure and dynamics of junction formation. Another approach is to study specific junction such as bile canaliculi formed between primary hepatocytes . Using microfabricated patterns with 3D protein coating we control the dynamics and position of bile canaliculi formation. Performing specifically developed techniques we image in real time the formation of the secretion tube and study how its formation is affected by physical parameters. Building on our experience with 3D protein coating in nano and microtextured environment, we are developing a platform for controlled cell culture, high resolution imaging and high through-put screening capabilities.
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论文共 107 篇作者统计合作学者相似作者
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Valentin Dunsing-Eichenauer,Johan Hummert,Claire Chardès, Thomas Schönau,Léo Guignard,Rémi Galland,Gianluca Grenci,Max Tillmann,Felix Koberling, Corinna Nock,Jean-Baptiste Sibarita,Virgile Viasnoff,
crossref(2024)
Valentin Dunsing-Eichenauer,Sham Tlili,Claire Chardes,Remi Galland,Jean-Baptiste Sibarita,Virgile Viasnoff,Leo Guignard,Pierre-Francois Lenne
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERSno. SUPPL 1 (2023): S78-S78
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Aditya Arora,Mohd Suhail Rizvi,Gianluca Grenci,Florian Dilasser,Chaoyu Fu, Modhura Ganguli, Sree Vaishnavi, Kathirvel Paramsivam,Srikanth Budnar, Ivar Noodstra,Alpha Yap,Virgile Viasnoff
biorxiv(2023)
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arXiv (Cornell University) (2023)
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Chaoyu Fu,Florian Dilasser, Shaao-Zhen Lin, Marc Karnat,Aditya Arora, Harini Rajendiran,Hui Ting Ong, Nai Mui Hoon, Sound Wai Phow,Tsuyoshi Hirashima, Michael Sheezt,Jean-Francois Rupprecht,
biorxiv(2023)
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