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Her research concerns chromosome structure and replication, with a focus on telomeres, the ends of chromosomes and replication fork progression through natural replication barriers. Throughout her career, she has been an advocate for women in science.
Virginia A. Zakian has made critical contributions in two areas of chromosome biology: telomeres and replication fork progression. Her work is characterized by a willingness to tackle important questions, use of a wide variety of experimental approaches, and novel findings. Her lab used ciliates to isolate the first telomere single-‐strand DNA binding proteins, the prototype of Pot1, and demonstrated that they protect DNA ends from degradation. Her lab discovered telomeric silencing and cell cycle dependent degradation of C-‐strand telomeric DNA in budding yeast, features now known to occur in diverse eukaryotes. They also identified proteins and events required for cell cycle and length-‐dependent regulation of telomerase.
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PLoS geneticsno. 7 (2023): e1010853-e1010853
Nature Communicationsno. 1 (2017): 15025-15025
semanticscholar(2016)
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