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个人简介
Dr. Lee’s research focuses on disease proteins that form pathological inclusions in hereditary and sporadic Alzheimer’s disease (AD), Parkinson’s disease (PD), frontotemporal lobar degeneration (FTLD), amyotrophic lateral sclerosis (ALS) and related neurodegenerative disorders of aging. Her work demonstrated that tau, alpha-synuclein and TDP-43 proteins form unique brain aggregates in neurodegenerative diseases and provided critical evidence that aggregation of brain proteins is a common mechanistic theme in diverse neurodegenerative diseases including AD, PD, FTLD, ALS and related disorders. Significantly, Dr. Lee’s studies implicated the abnormal aggregation of tau, alpha-synuclein and TDP-43 in mechanisms that compromise neuronal viability. Most importantly, this research has opened up new avenues of research to identify targets for drug discovery to develop better treatments for these disorders.
研究兴趣
论文共 1144 篇作者统计合作学者相似作者
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Hong Xu,Qi Qiu,Peng Hu, Kevt’her Hoxha, Elliot Jang, Mia O’Reilly, Christopher Kim,Zhuohao He,Nicholas Marotta,Lakshmi Changolkar,Bin Zhang,Hao Wu,
Celeste Parra Bravo,Alice Maria Giani,Jesus Madero Perez,Zeping Zhao, Yuansong Wan,Avi J. Samelson,Man Ying Wong, Alessandro Evangelisti, Ethan Cordes,Li Fan,Pearly Ye, Daphne Zhu,
Noah Lubben,Julia K Brynildsen,Cheryl E.G. Leyns, Connor M Webb,Howard L Li,Lakshmi Changolkar,Bin Zhang,Emily Meymand, Mia O'Reilly,Zach Madaj,Daniella DeWeerd,Matthew J Fell,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Research Square (Research Square) (2023)
Shujing Zhang,Ruowei Zhu,Buyan Pan,Hong Xu,Modupe F. Olufemi,Ronald J. Gathagan,Yuanxi Li,Luyan Zhang,Jasmine Zhang, Wenxuan Xiang, Eliot Masahiro Kagan,Xingjun Cao,
medRxiv : the preprint server for health sciences (2023)
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Shujing Zhang, Ruowei Zhu,Buyan Pan,Hong Xu,Modupe F. Olufemi,Ronald J. Gathagan,Yuanxi Li,Luyan Zhang,Jasmine Zhang, Wenxuan Xiang, Eliot Masahiro Kagan,Xingjun Cao,
Nature Neuroscienceno. 12 (2023): 2250-2250
Aaron J. Barbour,Sarah Gourmaud,David A. Stewart,Xiaofan Li, Sydney E Zebrowitz, Sarah Ferrigno,Virginia M.‐Y. Lee,Delia M. Talos,Frances E. Jensen
Alzheimer's & Dementiano. S1 (2023)
Ho Young Kim, Wai Kit Chia,Chia-Ju Hsieh, Dinahlee Saturnino Guarino,Thomas J A Graham,Zsofia Lengyel-Zhand,Mark Schneider, Cosette Tomita, Marshall G Lougee,Hee Jong Kim,Vinayak V Pagar,Hsiaoju Lee,
Journal of medicinal chemistryno. 17 (2023): 12185-12202
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