基本信息
浏览量:119
职业迁徙
个人简介
Research Interests
Integrated Cancer Genomic-Proteomic bioinformatics for therapeutics and translational research
Functional genomics and platform development for druggable mutations and driver mutations in human oncogenesis
Molecular mechanisms of mutation-based drug sensitivity for targeted therapies
Mechanisms of viral-mediated oncogenesis in aerodigestive tract cancers and Nasopharyngeal cancer
Patient-oriented pharmacogenomics
Publications
Hedberg, M.L., Goh, G., Chiosea, S.I., Bauman, J.E., Freilino, M.L., Zeng, Y., Wang, L., Diergaarde, B.B., Gooding, W.E., Lui, V.W., Herbst, R.S., Lifton, R.P. and Grandis, J.R. (2016). The genetic landscape of head and neck cancer recurrence and metastasis. J. Clin. Investigation, 126(1), 169-180.
Wen, Y., Li, H., Zeng, Y., Wen, W., Pendleton, K.P., Lui, V.W., Egloff, A.M. and Grandis, J.R. (2016). MAPK1(E322K) mutation increased head and neck suamous cell carcinoma sensitivity to erlotinib through enhanced secretion of amphiregulin. Oncotarget, 7(17), 23300-23311.
Li, H., Wheeler, S., Park, Y., Ju, Z., Thomas, S.M., Fichera, M., Egloff, A.M., Lui. V.W., Duvvuri, U., Bauman, J.E., Mills, G.B. and Grandis, J.R. (2016). Proteomic characterization of head and neck cancer patient-derived xenografts. Mol. Cancer Res., 14(3), 278-286.
Van Allen, E.M.*, Lui, V.W.*, Egloff, A.M., Goetz, E.M., Li, H., Johnson, J.T., Duvvuri, U., Bauman, J.E., Stransky, N., Zeng, Y., Gilbert, B.R., Pendleton, K.P., Wang, L., Chiosea, S., Sougnez, C., Wagle, N., Zhang, F., Du, Y., Close, D., Johnston, P.A., McKenna, A., Carter, S.L., Golub, T.R., Getz, G., Mills, G.B., Garraway, L.A. and Grandis, J.R. (2015). Genomic correlate of exceptional erlotinib response in head and neck squamous cell carcinoma. JAMA Oncology, 1(2), 238-244. *Co-first authorships.
Du, Y., Peyser, N.D., Li, H., Lui, V.W., Xiao, X., Maciej, Fiefing, Chan, T.A. and Grandis, J.R. (2015). Loss-of-function PTPRD mutations lead to increased STAT3 activation and sensitivity to STAT3 inhibition in head and neck cancer. PLos One, 10(8), e0135750.
Yau, N.K., Fong, A.Y., Leung, H.F., Verhoeft, K.R., Lim, Q.Y., Lam, W.Y., Wong, I.C. and Lui, V.W. (2015). A Pan-Cancer review of ALK mutations: Implications for Carcinogenesis and Therapy. Current Cancer Drug Targets, 15(4), 327-336.
Sen, M., Pollock, N.I., Black, J., DeGrave, K.A., Wheeler, S., Freilino, M.L., Joyce, S., Lui, V.W., Zeng, Y., Chiosea, S.I. and Grandis, J.R. (2015). JAK Kinase Inhibition Abrogates STAT3 Activation and Head and Neck Squamous Cell Carcinoma Tumor Growth. Neoplasia, 17(3), 256-264.
Wong, E.Y., Wong, S.C., Chan, C.M., Lam, E.K., Ho, L.Y., Lau, C.P., Au, T.C., Chan, A.K., Tsang, C.M., Tsao, S.W., Lui, V.W. and Chan, A.T. (2015). TP53-induced glycolysis and apoptosis regulator promotes proliferation and invasiveness of nasopharyngeal carcinoma cells. Oncology Letters, 9, 569-574. (*Corresponding author).
研究兴趣
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