Viviana Gradinaru
教授
Andrew and Peggy Cherng Department of Medical Engineering
Division of Engineering and Applied Science, California Institute of Technology;Tianqiao and Chrissy Chen Institute for Neuroscience, California Institute of Technology;Division of Biology and Biological Engineering, California Institute of Technology
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个人简介
Professor Gradinaru's research has focused on developing technologies for neuroscience and using them to probe circuits underlying locomotion, reward, and sleep. Together with collaborators, mentors, and trainees, Gradinaru has developed and applied neuronal activity readout and control tools such as optogenetics (Gradinaru et al, Cell 2010) and tissue clearing by CLARITY (Yang et al, Cell 2014; Gradinaru et al, Annual Review of Biophysics 2018) to dissect circuitry underlying movement, mood, and sleep disorders (Gradinaru et al, Science, 2009; Xiao et al, Neuron, 2016; Cho et al, Neuron, 2017). To extract functional information from cleared tissue the group also reported on methods for multi-color, multi-RNA imaging in deep tissue. In most recent work, to facilitate delivery of genetic controllers and sensors they have developed viral vector screening methods, with first efforts resulting in capsids capable of crossing the Blood-Brain-Barrier for non-invasive brain-wide transduction in adults after systemic delivery (Deverman et al, Nat.Biotech.2016) and a method for sparse stochastic Golgi-like genetic labeling for morphology assessment (Chan et al, NatureNeurosc. 2017); ongoing work in this area focuses on improving viral vectors for cell-type specificity and larger packaging ability (Bedbrook et al, Annual Review of Neuroscience 2018)
Prof. Gradinaru has received the NIH Director's New Innovator Award and a Presidential Early Career Award for Scientists and Engineers and has been honored as a World Economic Forum Young Scientist and as one of Cell's 40 under 40. Gradinaru is also a Sloan Fellow, Pew Scholar, Moore Inventor, Vallee Scholar, and Allen Brain Institute NGL Council Member, and received the inaugural Peter Gruss Young Investigator Award by the Max Planck Florida Institute for Neuroscience. In 2017 she was the Early-Career Scientist Winner in the Innovators in Science Award in Neuroscience (Takeda and the New York Academy of Sciences) and in 2018 she received a Gill Transformative award.
Viviana Gradinaru has also been very active in teaching and service, participating with lab members in regular technology training workshops at Caltech and for summer courses at Cold Spring Harbor Laboratory as well as running the CLOVER Center (Beckman Institute for CLARITY, Optogenetics and Vector Engineering), which provides training and access to the group's reagents and methods for the broader research community.
Prof. Gradinaru has received the NIH Director's New Innovator Award and a Presidential Early Career Award for Scientists and Engineers and has been honored as a World Economic Forum Young Scientist and as one of Cell's 40 under 40. Gradinaru is also a Sloan Fellow, Pew Scholar, Moore Inventor, Vallee Scholar, and Allen Brain Institute NGL Council Member, and received the inaugural Peter Gruss Young Investigator Award by the Max Planck Florida Institute for Neuroscience. In 2017 she was the Early-Career Scientist Winner in the Innovators in Science Award in Neuroscience (Takeda and the New York Academy of Sciences) and in 2018 she received a Gill Transformative award.
Viviana Gradinaru has also been very active in teaching and service, participating with lab members in regular technology training workshops at Caltech and for summer courses at Cold Spring Harbor Laboratory as well as running the CLOVER Center (Beckman Institute for CLARITY, Optogenetics and Vector Engineering), which provides training and access to the group's reagents and methods for the broader research community.
研究兴趣
论文共 198 篇作者统计合作学者相似作者
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bioRxiv : the preprint server for biology (2024)
Molecular Therapy (2024)
Cell Reportsno. 4 (2024): 113953-113953
Timothy F Shay,Seongmin Jang,Xinhong Chen, Beth Walker, Claire Tebbutt,Damien A Wolfe, Tyler J Brittain,Cynthia M Arokiaraj,Erin E Sullivan,Xiaozhe Ding,Ting-Yu Wang, Yaping Lei,
biorxiv(2024)
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Gerard M Coughlin,Máté Borsos, Nathan Appling, Bre'Anna H Barcelona, Acacia M H Mayfield,Elisha D Mackey, Rana A Eser,Xinhong Chen,Sripriya Ravindra Kumar,Viviana Gradinaru
bioRxiv : the preprint server for biology (2023)
MOLECULAR THERAPYno. 4 (2023): 21-21
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MOLECULAR THERAPYno. 4 (2023): 188-188
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Timothy F Shay,Erin E Sullivan,Xiaozhe Ding,Xinhong Chen,Sripriya Ravindra Kumar,David Goertsen,David Brown, Anaya Crosby,Jost Vielmetter,Máté Borsos,Damien A Wolfe, Annie W Lam,
MOLECULAR THERAPYno. 4 (2023): 228-228
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Miguel Chuapoco,Nicholas Flytzanis,Nick Goeden, J Octeau, Kristina Roxas,Ken Chan,Jon Scherrer,Janet Winchester, Roy Blackburn,Lillian Campos, Kwun-Nok Man,Junqing Sun,
Research Square (Research Square) (2023)
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