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职业迁徙
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We study how stem cells balance the competing needs of self-renewal and differentiation during organogenesis and tissue maintenance, as a means to understand the fundamental biology of stem cells and provide insights for their therapeutic use in treating disease and injury. Currently, we use Numb proteins, which segregate asymmetrically to distinguish the two daughter cells after an asymmetric cell division, as an entry point to examine how neural stem (progenitor) cells are regulated during mouse embryogenesis. We propose and seek to demonstrate a cell-intrinsic mechanism that is generally applicable to somatic stem cells, regardless of their tissue of origin, for their progeny to choose between self-renewal and differentiation. We have generated a set of unique mouse strains that can be used to manipulate stem-cell behavior in various tissues and will use cutting-edge molecular and genetic tools to identify key regulators that enable stem cells to generate diverse cell types.
研究兴趣
论文共 24 篇作者统计合作学者相似作者
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Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2014)
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2014)
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2014)
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2013)
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2013)
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2013)
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2013)
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