In biology and medical science areas, Weixiong Zhang is interested in developing computational methods for complex problems appeared in molecular biology, genetics, systems biology and genomics. He is particularly interested in applying computational methods to the understanding of complex human diseases, including Alzheimer’s disease and psoriasis, and environmental stress response in agri-economically important plants, such as rice and cassava. In recent years, he has been focusing on three lines of biological research: gene regulation through small noncoding RNAs, transcriptome analysis and genotype-phenotype association.