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Hematology and Stem Cell Biology
As a professor in Hematology and Stem Cell Biology, his research has focused on the development of Cellular Therapies, resulting in a translational and clinical program using Advanced Therapy Medicinal Products (ATMP) in a variety of clinical indications. His cell therapy work has also been important for the further development of regenerative medicine within LUMC and has been at the basis of the foundation of the Leiden Regenerative Medicine Platform. This Foundation aims to promote the translation of novel ATMP to patients. This work is well aligned with one of the major routes of the National Science Agenda, namely Regenerative Medicine.
In another research line he worked on the characterisation and biology of mesenchymal stromal cells and on in vitro mechanisms underlying their immune suppressive properties. This formed the basis for the clinical introduction of mesenchymal stromal cells for their immune-modulatory properties in the context of haplo- identical stem cell transplantation. Following the introduction into the clinic in 2003, an extensive translational and clinical program has developed in close collaboration with many clinical departments. Current research focusses on the further dissection of mechanisms underlying their therapeutic effects. He is the coordinator of a large European Consortium to perform a randomised phase III study for patients with acute graft-versus-host disease following transplantation.
As a professor in Hematology and Stem Cell Biology, his research has focused on the development of Cellular Therapies, resulting in a translational and clinical program using Advanced Therapy Medicinal Products (ATMP) in a variety of clinical indications. His cell therapy work has also been important for the further development of regenerative medicine within LUMC and has been at the basis of the foundation of the Leiden Regenerative Medicine Platform. This Foundation aims to promote the translation of novel ATMP to patients. This work is well aligned with one of the major routes of the National Science Agenda, namely Regenerative Medicine.
In another research line he worked on the characterisation and biology of mesenchymal stromal cells and on in vitro mechanisms underlying their immune suppressive properties. This formed the basis for the clinical introduction of mesenchymal stromal cells for their immune-modulatory properties in the context of haplo- identical stem cell transplantation. Following the introduction into the clinic in 2003, an extensive translational and clinical program has developed in close collaboration with many clinical departments. Current research focusses on the further dissection of mechanisms underlying their therapeutic effects. He is the coordinator of a large European Consortium to perform a randomised phase III study for patients with acute graft-versus-host disease following transplantation.
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Brenda Leeneman,Hedwig M. Blommestein, Annemieke van Dongen-Leunis,Mattia Algeri,Willem E. Fibbe,Liesbeth Oosten,Carin A. Uyl-de Groot,Frederick W. Thielen
Journal of the American Society of Nephrology : JASNno. 10 (2023): 1733-1751
HEMASPHEREno. 5 (2022): e0714-e0714
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