基本信息
浏览量:246
职业迁徙
个人简介
Research Statement
Electrical signaling is crucial for sensation, learning, memory, hormonal regulation, movement, and many other processes from single-celled organisms to man. We study the voltage-gated sodium and calcium channels that initiate action potential generation and synaptic transmission in nerve and muscle cells. We discovered these channel proteins in the 1980’s, analyzed their structure and function in the 1990’s and 2000’s, and determined their structures at atomic resolution using X-ray crystallography and cryo-electron microscopy in the past decade. We now probe their mechanisms of voltage-dependent gating, ion conductance and selectivity, pharmacological modulation, and second-messenger regulation in atomic detail. Recent studies have revealed the complete conformational cycle for sodium channel gating, the mechanism of action of mutations that cause periodic paralysis, and the sites and mechanisms of action of the local anesthetic and antiarrhythmic drugs that block sodium channels and the calcium antagonist drugs that block calcium channels. We also study ion channelopathies that are caused by mutations and dysregulation of voltage-gated sodium and calcium channels in the context of periodic paralysis, cardiac arrhythmia, epilepsy, and autism, using a combination of electrophysiology, molecular and structural biology, mouse genetics, and behavior.
Electrical signaling is crucial for sensation, learning, memory, hormonal regulation, movement, and many other processes from single-celled organisms to man. We study the voltage-gated sodium and calcium channels that initiate action potential generation and synaptic transmission in nerve and muscle cells. We discovered these channel proteins in the 1980’s, analyzed their structure and function in the 1990’s and 2000’s, and determined their structures at atomic resolution using X-ray crystallography and cryo-electron microscopy in the past decade. We now probe their mechanisms of voltage-dependent gating, ion conductance and selectivity, pharmacological modulation, and second-messenger regulation in atomic detail. Recent studies have revealed the complete conformational cycle for sodium channel gating, the mechanism of action of mutations that cause periodic paralysis, and the sites and mechanisms of action of the local anesthetic and antiarrhythmic drugs that block sodium channels and the calcium antagonist drugs that block calcium channels. We also study ion channelopathies that are caused by mutations and dysregulation of voltage-gated sodium and calcium channels in the context of periodic paralysis, cardiac arrhythmia, epilepsy, and autism, using a combination of electrophysiology, molecular and structural biology, mouse genetics, and behavior.
研究兴趣
论文共 529 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
British journal of pharmacology (2023): S145-S222
Proceedings of the National Academy of Sciences of the United States of Americano. 14 (2023)
引用2浏览0引用
2
0
British Journal of Pharmacologyno. S2 (2023): S145-S222
IUPHAR/BPS guide to pharmacology CITEno. 1 (2023)
引用0浏览0引用
0
0
Cell reports methodsno. 9 (2023): 100559-100559
引用0浏览0WOS引用
0
0
Nature Cardiovascular Researchno. 6 (2023): 587-594
BIOPHYSICAL JOURNALno. 3 (2023): 106A-106A
引用0浏览0引用
0
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn