His research in computational neuroscience concentrates on models of spiking neurons, the dynamics of spiking neural networks and spike-timing dependent plasticity. More recently, he got interested in generalizations of Hebbian learning in the form of multi-factor learning rules and in the role of surprise for learning. He currently has a joint appointment at the School of Life Sciences and the School of Computer and Communications Sciences at the EPFL. He teaches courses for Physicists, Computer Scientists, Mathematicians, and Life Scientists. He is the recipient of the Valentino Braitenberg Award for Computational Neuroscience 2018 and a member of the Academy of Sciences and Literature Mainz (Germany).