Dr. Wan’s long-term career goals are to understand how zoonotic pathogens (especially influenza A viruses) emerge and re-emerge at the animal-human interface and to improve the effectiveness of the influenza vaccines in disease prevention and control by developing and applying systems biology based translational approaches. Translational systems biology is an integrated, multi-scale, evidence-based approach that combines laboratory, clinical and computational methods with an explicit goal of developing effective means of control of biological processes for improving human health and rapid clinical application.