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Within his research program, Dr. Smith seeks to understand the pathophysiology of Parkinson's Disease (PD) and characterize changes in the synaptic plasticity of the basal ganglia in normal and pathological conditions. To achieve these goals, the Smith lab has developed a collaborative, interdisciplinary research program that uses in vitro and in vivo anatomical, electrophysiological, pharmacological and brain imaging approaches to study the functional organization of the basal ganglia in normal nonhuman primates and in nonhuman primate models of PD. This work is complemented with behavioral studies of novel surgical and pharmacologic therapies for PD in nonhuman primates.
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MOLECULAR THERAPYno. 4 (2023): 194-194
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bioRxiv (Cold Spring Harbor Laboratory) (2023)
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