基本信息
浏览量:24
职业迁徙
个人简介
Research Directions
i) To search for the genetic causes of vascular cognitive impairment and dementia
50 million people worldwide are now suffering from dementia; however, the exact causes remain elusive. Vascular Cognitive Impairment and Dementia (VCID) due to cerebrovascular diseases and pathologies represents 20~40% of the dementia cases, and largely overlaps with AD in terms of pathologies and pathogenic factors. Recently, we have been working with two groups of genetic risk factors that are vascular residents but can either predispose individual to cerebrovascular diseases or strongly modify the course of AD and VCID, such as platelet-derived growth factor receptor beta (PDGFRß), LRP1 and PICALM. Although this is just the first peek through the looking glass, yet our finding has brought new insight into the genetic causes of VCID and AD, suggesting that a better understanding the etiology and pathogenesis of AD and VICD, especially decoding the common genetic causes may help us redefining a subset of cases, and land more effective therapeutics for them in the near future.
i) To search for the genetic causes of vascular cognitive impairment and dementia
50 million people worldwide are now suffering from dementia; however, the exact causes remain elusive. Vascular Cognitive Impairment and Dementia (VCID) due to cerebrovascular diseases and pathologies represents 20~40% of the dementia cases, and largely overlaps with AD in terms of pathologies and pathogenic factors. Recently, we have been working with two groups of genetic risk factors that are vascular residents but can either predispose individual to cerebrovascular diseases or strongly modify the course of AD and VCID, such as platelet-derived growth factor receptor beta (PDGFRß), LRP1 and PICALM. Although this is just the first peek through the looking glass, yet our finding has brought new insight into the genetic causes of VCID and AD, suggesting that a better understanding the etiology and pathogenesis of AD and VICD, especially decoding the common genetic causes may help us redefining a subset of cases, and land more effective therapeutics for them in the near future.
研究兴趣
论文共 114 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Acta Neuropathologica Communicationsno. 1 (2024): 1-3
Liangguang Leo Lin,Huilun Helen Wang, Brent Pederson,Xiaoqiong Wei,Mauricio Torres,You Lu,Zexin Jason Li, Xiaodan Liu,Hancheng Mao,Hui Wang, Linyao Elina Zhou,Zhen Zhao,
Nature Communicationsno. 1 (2024): 1-20
Haowen Qiao, Xiangxue Deng, Lingxi Qiu, Yafei Qu, Yuanpu Chiu, Feixiang Chen,Shangzhou Xia, Cheyene Muenzel,Tenghuan Ge, Pengfei Song,Alexandre Bonnin,Zhen Zhao,
biorxiv(2024)
Nature Neuroscienceno. 1 (2024): 208-208
引用0浏览0WOSNATURE引用
0
0
Qingyi Ma,Zhen Zhao, Abhay P. Sagare,Yingxi Wu,Min Wang, Nelly Chuqui Owens,Philip B. Verghese,Joachim Herz,David M. Holtzman,Berislav V. Zlokovic
Guang-Wei Zhang,Shangzhou Xia, Nicole K. Zhang,Fan Gao,Berislav V. Zloković,Li I. Zhang,Zhen Zhao,Huizhong W. Tao
bioRxiv (Cold Spring Harbor Laboratory) (2023)
NATURE COMMUNICATIONSno. 1 (2023)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn