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Bio
With primary interests in the mechanisms of immune regulation in cancer, my research team has made seminal contributions to understanding the immunological properties of heat shock proteins in cancer immunotherapy and immune tolerance. We provided the first genetic evidence linking the heat shock response to antigen cross-presentation and adaptive immunity; pioneered the use of autologous, tumor-derived HSP70-peptide complex for the immunotherapy of leukemia; and discovered that gp96, a paralog in the endoplasmic reticulum, is the master molecular chaperone for Toll-like receptors (TLRs).
I am internationally recognized as a leader in the field of gp96 biology due to a number of contributions such as the discovery of its ATPase activity, peptide-binding properties and client-binding domain. My current research interests focus on developing better immunotherapeutics against cancer by reprogramming the tolerogenic tumor microenvironment, including regulatory T-cells, thrombocytes and unfolded protein response. My work is supported by the National Institutes of Health, including a program project grant from the National Cancer Institute and four RO1s for which I am principal investigator.
I am also widely published in scientific journals on the topics of immune tolerance, cancer immunology and chaperone biology, and serve as an elected member of such professional organizations as the American Society for Clinical Investigation (ASCI) and the Association of American Physicians (AAP).
Research Interests
Papers共 326 篇Author StatisticsCo-AuthorSimilar Experts
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Frontiers in Applied Mathematics and Statistics (2024)
Rahul Shivahare,No Joon Song, Bahareh Nourmohammadi, Jemal Imam, Olivia Sanabria,Joseph M. Amann, Qin Ma,Zihai Li,David P. Carbone,Jacob Kaufman
Cancer Researchno. 6_Supplement (2024): 6529-6529
Journal for immunotherapy of cancerno. 1 (2024): e007922-e007922
The Journal of clinical investigation/The journal of clinical investigation (2024)
Hyunwoo Kwon,Mingjia Li,Jesse D. Sheldon, Nicholas Jones, Nicolas Gallastegui Crestani,Zihai Li,Dwight H. Owen
Current problems in cancer Case reports (2024): 100275-100275
Nature Communicationsno. 1 (2024)
Dixita M. Patel, Ruba Mateen, Noor Qaddour,Alessandra Carrillo,Claire Verschraegen,Yuanquan Yang,Zihai Li,Debasish Sundi,Amir Mortazavi,Katharine A. Collier
Cancersno. 2 (2024): 335
pubmed(2024)
Nature communicationsno. 1 (2024)
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Author Statistics
#Papers: 326
#Citation: 10721
H-Index: 57
G-Index: 96
Sociability: 8
Diversity: 0
Activity: 4
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