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职业迁徙
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Research Interests
Cellular and molecular basis of hematopoietic stem cell and tissue-resident macrophage development; the roles of microglia and Langerhans cells in organ development and tissue regeneration.
Wen’s laboratory is keen to understand the developmental mechanism that establishes the cellular components of the blood system and how their dysregulation incurs diseases by utilizing zebrafish (Danio rerio), a tiny tropical fish whose blood system shares many similarities to human. A combination of photo-inducible lineage tracing, time-lapse imaging and devising genetic strategies will be employed to investigate the origin, migration and colonization, fate determination and function of hematopoietic stem cells, microglia and Langerhans cells in the intact developing and adult zebrafish with highest possible cellular resolution. The ultimately goal is to uncover novel cellular and molecular principles that organize the formation, maintenance and function of these hematopoietic cells under physiological and pathological states.
研究兴趣
论文共 141 篇作者统计合作学者相似作者
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Development (Cambridge, England)no. 3 (2024)
Ao Zhang, Jingao Lu,Shachuan Feng, Huapeng Yu,Tao Yu,Shizheng Zhao, Kemin Chen,Zhibin Huang,Jin Xu,Jianan Y. Qu,Zilong Wen
Wenwei Sun,Meimei Wang,Jun Zhao, Shuang Zhao,Wenchao Zhu, Xiaoting Wu,Feifei Li,Wei Liu, Zhuo Wang,Meng Gao,Yiyue Zhang,Jin Xu,
Advances in Experimental Medicine and Biology Hematopoietic Stem Cells (2023): 137-157
Qiuxia Zhou,Changlong Zhao, Zhiyong Yang, Rui Qu,Yunbo Li, Yining Fan,Jinlin Tang,Ting Xie,Zilong Wen
Cell reportsno. 7 (2023): 112793-112793
Science advancesno. 24 (2023)
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Cell reportsno. 5 (2023): 112483-112483
Xianwei Chen, Yanfeng Li,Jin Xu,Yong Cui,Qian Wu,Haidi Yin, Yuying Li,Liwen Jiang,Huating Wang,Zilong Wen,Zhongping Yao,Zhenguo Wu
bioRxiv (Cold Spring Harbor Laboratory) (2022)
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