Cytotoxicity, Pharmacokinetics and Antitumor Efficacy of a Novel Liposomal Mitoxantrone
Biomedical Engineering and Biotechnology（2012）
摘要
This investigation is based on a novel formulation of mitoxantrone liposome (LEM) with high encapsulation efficiency and good stability. Cytotoxicity of LEM tumor cell line was studied in vitro, and the result showed that cytotoxicity of LEM in HL-60 cell lines were comparable to that of free MTO. Pharmacokinetics parameters of LEM was investigated in Beagal dogs plasma with a prolonged circulation time and a decreased clearance time as compared with that of free mitonxantrane (MTO). In the in vivo antitumor studies, different tumor models of leukemia in CD2F1 mice and breast cancer in athymic mice were used to determine the antitumor activities of LEM. The results showed that as compared with free MTO, LEM had a much stronger antitumor activities, and the statistically differences were significantly. These results indicate the MTO liposomal formulation could be a new promising MTO pharmaceutics for treatment of malignant disease in clinic.
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关键词
pharmacokinetics parameters,liposomes,new promising mto pharmaceutics,pharmacokinetics,antitumor activity,athymic mice,cellular biophysics,malignant disease treatment,prolonged circulation time,clearance time,hl-60 cell line,mto liposomal formulation,beagal dogs plasma,mitoxantrone,vivo antitumor study,free mitonxantrane,hl-60 cell lines,lipid bilayers,stronger antitumor activity,novel liposomal mitoxantrone,cancer,cytotoxicity,breast cancer,free mto,lem tumor cell line,tumours,high encapsulation efficiency,leukemia,antitumor efficacy,patient treatment,cd2f1 mice,plasmas,encapsulation
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