Synthetic dihydropacidamycin antibiotics
Bioorganic & Medicinal Chemistry Letters(2003)
摘要
Dihydropacidamycins having an antibacterial spectrum modified from that of the natural product pacidamycins and mureidomycins have been synthesized. Synthetic dihydropacidamycins with noteworthy antibacterial activity against wild-type and resistant Escherichia coli have been identified (MIC=4–8 μg/mL). Some dihydropacidamycins are shown to have activity against multi-resistant clinical strains of Mycobacterium tuberculosis. Compounds of this class are inhibitors of the cell wall biosynthetic enzyme, MraY.
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关键词
escherichia coli,cell wall,enzyme,spectrum,wild type
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