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Mycobacterial catalase-peroxidase is a tissue antigen and target of the adaptive immune response in systemic sarcoidosis.

JOURNAL OF EXPERIMENTAL MEDICINE, no. 5 (2005): 755-767

Cited: 266|Views7

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peroxidaseadaptive immunityrecombinant proteinsin situ hybridizationdna

Abstract

Sarcoidosis is a disease of unknown etiology characterized by noncaseating epithelioid granulomas, oligoclonal CD4(+)T cell infiltrates, and immune complex formation. To identify pathogenic antigens relevant to immune-mediated granulomatous inflammation in sarcoidosis, we used a limited proteomics approach to detect tissue antigens that w...More

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