Evaluation of liver and peripheral blood micronucleus assays with 9 chemicals using young rats

Hiroshi Suzuki,Naohiro Ikeda,Kazuo Kobayashi,Yukari Terashima,Yasushi Shimada,Takayoshi Suzuki,Toshiyuki Hagiwara,Shigeki Hatakeyama,Koko Nagaoka,Junichi Yoshida,Yukiko Saito,Jin Tanaka,Makoto Hayashi

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2005）

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摘要

We conducted simultaneous liver and peripheral blood micronucleus assays in young rats with seven rodent hepatocarcinogens—4,4′-methylenedianiline (MDA), quinoline, o-toluidine, 4-chloro-o-phenylenediamine (CPDA), dimethylnitrosamine (DMN), p-dimethylaminoazobenzene (DAB), and di(2-ethylhexyl)phthalate (DEHP)—and two mutagenic chemicals—kojic acid and methylmethanesulfonate (MMS).

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关键词

Young rat,Liver micronucleus,Peripheral blood micronucleus,Hepatocarcinogen

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