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DNA methylation specifies chromosomal localization of MeCP2.

MOLECULAR AND CELLULAR BIOLOGY, no. 1 (1996): 414-421

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pubmed.ncbi.nlm.nih.gov academic.microsoft.com

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dna primerslac operondnamethylationrepressor proteinsMore(6+)

Abstract

MeCP2 is a chromosomal protein that is concentrated in the centromeric heterochromatin of mouse cells. In vitro, the protein binds preferentially to DNA containing a single symmetrically methylated CpG. To find out whether the heterochromatic localization of MeCP2 depended on DNA methylation, we transiently expressed MeCP2-LacZ fusion pro...More

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