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Development Of Rhabdomyosarcoma In Her-2/Neu Transgenic P53 Mutant Mice
CANCER RESEARCH, no. 11 (2003): 2728-2732
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Rhabdomyosarcomas derive from the skeletal muscle lineage and harbor a variety of genetic and molecular lesions. However, it is not clear which molecular alterations have a pathogenetic role. We show that activation of the HER-2/neu oncogene coupled with inactivation of the oncosuppressor gene p53 causes rhabdomyosarcoma in mice. At the a...更多
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