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Phosphorylation Of Parkin By The Cyclin-Dependent Kinase 5 At The Linker Region Modulates Its Ubiquitin-Ligase Activity And Aggregation
JOURNAL OF BIOLOGICAL CHEMISTRY, no. 17 (2007): 12842-12850
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Abstract
Mutations in Parkin are responsible for a large percentage of autosomal recessive juvenile parkinsonism cases. Parkin displays ubiquitin-ligase activity and protects against cell death promoted by several insults. Therefore, regulation of Parkin activities is important for understanding the dopaminergic cell death observed in Parkinson di...More
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