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Numerical analysis of a comprehensive model of M-phase control in Xenopus oocyte extracts and intact embryos.

Journal of cell science, (1993): 1153-1168

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To contribute to a deeper understanding of M-phase control in eukaryotic cells, we have constructed a model based on the biochemistry of M-phase promoting factor (MPF) in Xenopus oocyte extracts, where there is evidence for two positive feedback loops (MPF stimulates its own production by activating Cdc25 and inhibiting Wee1) and a negati...更多

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