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New highly potent and specific E6 and E7 siRNAs for treatment of HPV16 positive cervical cancer.

CANCER GENE THERAPY, no. 3 (2008): 140.0-153

被引用67|浏览5
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Persistent infection by high-risk types of human papillomaviruses (HPV) is a necessary cause of cervical cancer, with HPV16 the most prevalent, accounting for more than 50% of reported cases. The virus encodes the E6 and E7 oncoproteins, whose expression is essential for maintenance of the malignant phenotype. To select efficacious siRNAs...更多

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