The Discovery And Synthesis Of Highly Potent, A(2a) Receptor Agonists

Suzanne E. Keeling,F.David Albinson,Barry E. Ayres,Peter R. Butchers,C.Lynn Chambers,Peter C. Cherry,Frank Ellis,George B. Ewan,Michael Gregson,John Knight,Keith Mills,Paul Ravenscroft,Linda H. Reynolds,Shahin Sanjar,Michael J. Sheehan

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（2000）

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摘要

A series of N6,2-disubstituted adenosine analogues have been synthesized and their functional activity measured against A(2a) and A(1) receptors. Examples of compounds with both a lipophilic N6-substituent and amino-functionalized 2-position were highly active at the A(2a) receptor on the human neutrophil. (C) 2000 Published by Elsevier Science Ltd. All rights reserved.

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2a receptor agonists,synthesis

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