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Dimerization of the human E3 ligase CHIP via a coiled-coil domain is essential for its activity.

The Journal of biological chemistry, no. 4 (2004): 2673-2678

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The Hsp70-interacting E3-ubiquitin ligase CHIP has been implicated in the decision as to whether a target protein enters the refolding or the degradation pathway. To further characterize the activity of CHIP we purified untagged Homo sapiens and Drosophila melanogaster CHIP (hCHIP, dCHIP). In contrast to other E3-ubiquitin ligases, both h...更多

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