The structure-activity relationship study on 2-, 5-, and 6-position of the water soluble 1,4-dihydropyridine derivatives blocking N-type calcium channels.

Takashi Yamamoto,Seiji Niwa,Seiji Ohno,Munetaka Tokumasu,Yoko Masuzawa,Chika Nakanishi,Akira Nakajo,Tomoyuki Onishi,Hajime Koganei,Shin-Ichi Fujita,Tomoko Takeda,Morikazu Kito,Yukitsugu Ono,Yuki Saitou,Akira Takahara,Seinosuke Iwata,Masataka Shoji

Bioorganic & Medicinal Chemistry Letters（2008）

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摘要

The structure–activity relationship of the 2-, 5-, and 6-position of 1,4-dihydropyridine-3-carboxylic acid-derived N-type calcium channel blockers is reported.

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关键词

N-type calcium channel blocker,Structure–activity relationships,1,4-dihydropyridine derivative

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