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Cyclooxygenase Allosterism, Fatty Acid-Mediated Cross-Talk Between Monomers Of Cyclooxygenase Homodimers

JOURNAL OF BIOLOGICAL CHEMISTRY, no. 15 (2009): 10046-10055

Cited: 60|Views25
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Abstract

Prostaglandin endoperoxide H synthases (PGHSs) 1 and 2, also known as cyclooxygenases (COXs), catalyze the oxygenation of arachidonic acid ( AA) in the committed step in prostaglandin (PG) biosynthesis. PGHSs are homodimers that display half of sites COX activity with AA; thus, PGHSs function as conformational heterodimers. Here we show t...More

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