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Loss of Bim increases T cell production and function in interleukin 7 receptor-deficient mice.
JOURNAL OF EXPERIMENTAL MEDICINE, no. 9 (2004): 1189-1195
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摘要
Interleukin (IL)-7 receptor (R) signaling is essential for T and B lymphopoiesis by promoting proliferation, differentiation, and survival of cells. Mice lacking either IL-7 or the IL-71Ralpha chain have abnormally low numbers of immature as well as mature T and B lymphocytes. Transgenic expression of the apoptosis inhibitor Bcl-2 rescues...更多
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