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Level Of Human Tcrbv3s1 (V-Beta-3) Expression Correlates With Allelic Polymorphism In The Spacer Region Of The Recombination Signal Sequence

JOURNAL OF EXPERIMENTAL MEDICINE, no. 5 (1994): 1707-1711

Cited: 88|Views22
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Abstract

One of the causes of variations in the expressed human T cell receptor (TCR) BV (V beta) repertoire is genetic variation in the germline DNA. Herein evidence is provided that allelic polymorphism may affect recombination frequency for a specific V gene. Two alleles of the TCR BV3 differ only at a single nucleotide position (C/T) within th...More

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