The T/Ebp Null Mouse Thyroid-Specific Enhancer-Binding Protein Is Essential For The Organogenesis Of The Thyroid, Lung, Ventral Forebrain, And Pituitary

The thyroid-specific enhancer-binding protein (T/ebp) gene was disrupted by homologous recombination in embryonic stem cells to generate mice lacking T/EBP expression. Heterozygous animals developed normally, whereas mice homozygous for the disrupted gene were born dead and lacked the lung parenchyma. Instead, they had a rudimentary bronc...更多