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Crystal structure of a human mitochondrial deoxyribonucleotidase.
NATURE STRUCTURAL BIOLOGY, no. 10 (2002): 779.0-787.0
WOS NATURE
摘要
5' nucleotidases are ubiquitous enzymes that dephosphorylate nucleoside monophosphates and participate in the regulation of nucleotide pools. The mitochondrial 5'-(3') deoxyribonucleotidase (dNT-2) specifically dephosphorylates dUMP and dTMP, thereby protecting mitochondrial DNA replication from excess dTTP. We have solved the structure o...更多
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