Novel Coa-Polyamine Conjugates For Effective Inhibition Of Spermine/Spermidine-N-1-Acetyltransferase
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS(2007)
摘要
New mimics of the transition state of spermine/spermidine-N-1 -acetyltransferase reaction were prepared starting from aminooxy analogues of spermidine or spermine and SH-CoA. The activity depended on the structure of polyamine fragment of the conjugate and best of the synthesized compounds were active at micromolar concentrations.
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关键词
polyamines, coenzyme A, SSAT, coenzyme-substrate inhibitors
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