Inhibition Of Protein-Tyrosine Phosphatases By Mild Oxidative Stresses Is Dependent On S-Nitrosylation

Previous studies have shown that a Ca2+-dependent nitric-oxide synthase (NOS) is activated as part of a cellular response to low doses of ionizing radiation. Genetic and pharmacological inhibitor studies linked this NO signaling to the radiation-induced activation of ERK1/2. Herein, a mechanism for the radiation-induced activation of Tyr ...更多