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p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice.
NATURE GENETICS, no. 10.0 (2009): 1138-U125
WOS NATURE
摘要
Telomere dysfunction limits the proliferative capacity of human cells and induces organismal aging by activation of p53 and p21 (refs. 1-6). Although deletion of p21 elongates the lifespan of telomere-dysfunctional mice(2), a direct analysis of p53 in telomere-related aging has been hampered by early tumor formation in p53 knockout mice(6...更多
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