Syntheses of C-5-spirocyclic C-glycoside SGLT2 inhibitors

Vincent Mascitti,Ralph P. Robinson,Cathy Préville,Benjamin A. Thuma,Christopher L. Carr,Matthew R. Reese,Robert J. Maguire,Michael T. Leininger,André Lowe,Claire M. Steppan

Tetrahedron Letters（2010）

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摘要

Several syntheses of C-5-spirocycle-containing C-glycosides are discussed. A multigram-scale synthesis capitalizing on a one-pot aldol-Cannizzaro sequence is described. Spiro oxetane formation using an unprotected penta-ol C-glycoside as substrate is also exemplified.

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